Airway Mechanics, the Microbiome, and the Acceleration of Inflammation and Aging
- Develop a new perspective on the relationship between sinonasal anatomy and mechanics of breathing and its impact on the human bacterial biome
- Understand the relationship between gut ecology and the human immune system
- Understand the importance of prenatal and childhood nutrition in improving adult immune function
The very first structure to form in an embryo is the hard palate. All subsequent development of the gut, neural system in utero is founded on the health of this palate. The nutritional status of the mother during fetal development, and the child’s nutritional status during rapid growth phases of development are critical to the healthy formation and development of the adult palate. If nasal breathing capacity is undermined, we can see rapid impact on the health of the immune system, with the child becoming far more sensitive to the environment, from seasonal allergies to food sensitivities the system is under threat. The balance of the major bacterial genus’ are often impacted by sino-nasal health, with fermentation rather than carbohydrate metabolism becoming dominant digestive pathways. This shift can lead to inflammatory changes throughout the immune system of the gut. This talk unifies our understanding of fetal development and the risk of nutritional deficits from mother, to child, to the next generations.